The role of front-end electrode sensors for dopamine-detection brain implants is significant for the entire measurement process. The electrode material determines the sensitivity, selectivity, and longevity of the implant. Carbon-based electrode induces better dopamine adsorption due to π-interaction. We tested carbon fiber microelectrode (CFME) on aset of dopamine solution concentrations (1 mM to 0.01 mM) to determine its limit of detection and its reliability for quantitative analysis. The raw signal is processed using ∆Σ-converter and the concentration is estimated using a linear regression technique. The wireless feature is incorporated with a triple-band antenna at frequencies of 402, 902, and 2450 MHz for data communications, wireless power transmission, and switching control.