FR4.R6.3

On the Coverage Required for Diploid Genome Assembly

Daanish Mahajan, Chirag Jain, Navin Kashyap, Indian Institute of Science, India

Session:
Information and Coding in Biology

Track:
17: Information and Coding in Biology

Location:
Sigma/Delta

Presentation Time:
Fri, 12 Jul, 17:05 - 17:25

Session Chair:
Luca Barletta,
Abstract
[THIS PAPER IS ELIGIBLE FOR THE STUDENT PAPER AWARD.] We investigate the information-theoretic conditions to achieve the complete reconstruction of a diploid genome. We also analyze the standard greedy and de-Bruijn graph-based algorithms, and compare the coverage and read length requirements with the information-theoretic lower bound. Our results show that the gap between the two is considerable because both algorithms require the double repeats in the genome to be bridged.
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